Editorial: Redefining Medicine

Latest Research

  • Article |

    Excess anti-Müllerian hormone during pregnancy results in polycystic ovary syndrome-like phenotypes in female offspring, possibly explaining its pathogenesis as well as suggesting a possible therapy.

    • Brooke Tata
    • , Nour El Houda Mimouni
    • , Anne-Laure Barbotin
    • , Samuel A. Malone
    • , Anne Loyens
    • , Pascal Pigny
    • , Didier Dewailly
    • , Sophie Catteau-Jonard
    • , Inger Sundström-Poromaa
    • , Terhi T. Piltonen
    • , Federica Dal Bello
    • , Claudio Medana
    • , Vincent Prevot
    • , Jerome Clasadonte
    •  & Paolo Giacobini
  • Brief Communication |

    Treatment with setmelanotide, a new-generation MC4R agonist, provides durable weight loss in hyperphagic, leptin receptor–deficient patients, suggesting a pharmacological avenue to treat patients with various MC4R pathway defects.

    • Karine Clément
    • , Heike Biebermann
    • , I. Sadaf Farooqi
    • , Lex Van der Ploeg
    • , Barbara Wolters
    • , Christine Poitou
    • , Lia Puder
    • , Fred Fiedorek
    • , Keith Gottesdiener
    • , Gunnar Kleinau
    • , Nicolas Heyder
    • , Patrick Scheerer
    • , Ulrike Blume-Peytavi
    • , Irina Jahnke
    • , Shubh Sharma
    • , Jacek Mokrosinski
    • , Susanna Wiegand
    • , Anne Müller
    • , Katja Weiß
    • , Knut Mai
    • , Joachim Spranger
    • , Annette Grüters
    • , Oliver Blankenstein
    • , Heiko Krude
    •  & Peter Kühnen
  • Letter |

    Loss of mismatch-repair protein ARID1A in cancer correlates with high mutation load & checkpoint blockade response, complementing MSI-based prognosis.

    • Jianfeng Shen
    • , Zhenlin Ju
    • , Wei Zhao
    • , Lulu Wang
    • , Yang Peng
    • , Zhongqi Ge
    • , Zachary D. Nagel
    • , Jun Zou
    • , Chen Wang
    • , Prabodh Kapoor
    • , Xiangyi Ma
    • , Ding Ma
    • , Jiyong Liang
    • , Shumei Song
    • , Jinsong Liu
    • , Leona D. Samson
    • , Jaffer A. Ajani
    • , Guo-Min Li
    • , Han Liang
    • , Xuetong Shen
    • , Gordon B. Mills
    •  & Guang Peng
  • Letter |

    Expression of PM20D1 is regulated by long-range chromatin interactions with an Alzheimer’s disease risk haplotype, and PM20D1 overexpression reduces AD-like pathology and cognitive impairment in a rodent model.

    • Jose V. Sanchez-Mut
    • , Holger Heyn
    • , Bianca A. Silva
    • , Lucie Dixsaut
    • , Paula Garcia-Esparcia
    • , Enrique Vidal
    • , Sergi Sayols
    • , Liliane Glauser
    • , Ana Monteagudo-Sánchez
    • , Jordi Perez-Tur
    • , Isidre Ferrer
    • , David Monk
    • , Bernard Schneider
    • , Manel Esteller
    •  & Johannes Gräff
  • Letter |

    The transcription factor ELK-1 is upregulated in patients with major depressive disorder, and selective inhibition of hippocampal ELK-1 produces rapid antidepressive effects in rodent models of depression.

    • Kallia Apazoglou
    • , Séverine Farley
    • , Victor Gorgievski
    • , Raoul Belzeaux
    • , Juan Pablo Lopez
    • , Julien Grenier
    • , El Chérif Ibrahim
    • , Marie-Anne El Khoury
    • , Yiu C. Tse
    • , Raphaele Mongredien
    • , Alexandre Barbé
    • , Carlos E. A. de Macedo
    • , Wojciech Jaworski
    • , Ariane Bochereau
    • , Alejandro Orrico
    • , Elsa Isingrini
    • , Chloé Guinaudie
    • , Lenka Mikasova
    • , Franck Louis
    • , Sophie Gautron
    • , Laurent Groc
    • , Charbel Massaad
    • , Ferah Yildirim
    • , Vincent Vialou
    • , Sylvie Dumas
    • , Fabio Marti
    • , Naguib Mechawar
    • , Elise Morice
    • , Tak P. Wong
    • , Jocelyne Caboche
    • , Gustavo Turecki
    • , Bruno Giros
    •  & Eleni T. Tzavara

News & Comment

  • News & Views |

    Anti-GD2 chimeric antigen receptor (CAR)-modified T cells may be a new and innovative approach for the treatment of pediatric H3-K27M-mutant diffuse midline gliomas.

    • Vijay Ramaswamy
    •  & Michael D Taylor
  • News Feature |

    New studies question how HIV persists in the body

    • Shraddha Chakradhar
  • News & Views |

    A crucial role for glucose metabolism has been identified in wound repair and in the pathogenesis of chronic inflammatory skin diseases, indicating that targeting metabolism is an approach for treating psoriasis.

    • Paul Hiebert
    •  & Sabine Werner
  • Editorial |

    For more than two decades, Nature Medicine has been the prime venue for publication of outstanding work in the translational space. Now the journal’s scope is evolving to embrace the clinical research that meets the challenges and complexities of contemporary medicine.

  • News Feature |

    Finding poetry in gene editing and ways to improve it

    • Peter Andrey Smith
  • News & Views |

    In triple-negative breast cancer, therapeutic response to carboplatin and docetaxel is similar. However, carboplatin therapy is superior to docetaxel in patients with germline BRCA1 or BRCA2 mutations, but ‘BRCAness’ does not predict sensitivity to carboplatin. 

    • Ana C. Garrido-Castro
    •  & Eric P. Winer

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